Protein gradients in single cells induced by their coupling to “morphogen”-like diffusion

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Protein gradients in single cells induced by"morphogen"-like diffusion

One of the many ways cells transmit information within their volume is through steady spatial gradients of different proteins. However, the mechanism through which such single-cell gradients form is not yet fully understood. We first demonstrate that one of the models for gradient formation, based on differential diffusion, is limited to proteins with large ratios of their diffusion constants o...

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Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is unclear. We attempt to resolve this controversy by analyzing recent data in w...

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ژورنال

عنوان ژورنال: The Journal of Chemical Physics

سال: 2018

ISSN: 0021-9606,1089-7690

DOI: 10.1063/1.5021086